Comparative analysis of the levels of soluble forms of receptor and ligand of the immunity control point PD-1 / PD-L1 in the blood serum of patients with typical bone osteosarcoma and chondrosarcoma
| Autor: | Yu S Timofeev, A A Alferov, M M Efimova, O T Khvan, M Yu Shchupak, E A Korotkova, N Yu Sokolov, N. E. Kushlinskii, Yu B Kuzmin, E A Sushentsov, I. V. Boulytcheva, I N Kuznetsov, M. D. Aliev, E. S. Gershtein, E R Musaev, A V Bondarev |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Biochemistry (medical) General Medicine Bone Osteosarcoma medicine.disease 03 medical and health sciences Medical Laboratory Technology 0302 clinical medicine Blood serum Primary bone 030220 oncology & carcinogenesis PD-L1 mental disorders medicine biology.protein Osteosarcoma Sarcoma Chondrosarcoma business Receptor 030215 immunology |
| Zdroj: | Russian Clinical Laboratory Diagnostics. 65:669-675 |
| ISSN: | 2412-1320 0869-2084 |
| Popis: | Results of ELISA investigation of the pretreatment sPD-1 and sPD-L1 content in blood serum of 133 bone neoplasms patients aged 6-70 years and 57 practically healthy control persons aged 12-70 years are described. In 14 patients the neoplasms were of a benign character, in 16 - borderline giant-cell bone tumor was diagnosed, and in 103 - malignant bone lesions including 39 osteosarcomas and 42 chondrosarcomas were revealed. The sPD-1 receptor concentrations in blood serum did not differ between control healthy persons and primary bone tumor patients, while serum sPD-L1 level in bone tumor patients was statistically significantly increased (p |
| Databáze: | OpenAIRE |
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