Synthesis and antimycobacterial activity of N-isonicotinoyl-N′-alkylideneferrocenecarbohydrazides
| Autor: | Alexey N. Rodionov, V. N. Babin, Yu. A. Belousov, V. N. Kulikov, R. S. Nikulin, E. S. Babusenko, L. V. Kovalenko |
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| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Hydrochloride medicine.drug_class Stereochemistry Isoniazid General Chemistry 010402 general chemistry biology.organism_classification Antimycobacterial 01 natural sciences Chloride Corpus albicans 0104 chemical sciences Acylation chemistry.chemical_compound chemistry Pyridine medicine Mycobacterium medicine.drug |
| Zdroj: | Russian Chemical Bulletin. 66:1122-1125 |
| ISSN: | 1573-9171 1066-5285 |
| Popis: | Acylation of ferrocenoylhydrazones with isonicotinoyl chloride hydrochloride in pyridine was used to obtain a number of new N-isonicotinoyl-N′-ylideneferrocenecarbohydrazides in 50–95% yields. The obtained compounds were characterized by NMR and IR spectroscopy and mass-spectrometry. Some of the obtained compounds were found to exhibit pronounced antimycobacterial activity against the Mycobacterium rubrum strain and to have no toxicity with respect to the P. aeruginosa, E. coli, S. aureus, B. subtilis, and C. albicans strains. |
| Databáze: | OpenAIRE |
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