EFFECT OF METFORMIN AND SIMVASTATIN IN DIAZEPAM-AND SODIUM NITRITE-INDUCED ANTEROGRADE AMNESIA IN MALE SWISS ALBINO MICE

Autor:	S. S. Torgal, C H Sugato
Rok vydání:	2018
Předmět:	Pharmacology Anterograde amnesia business.industry Sodium Pharmaceutical Science Amnesia chemistry.chemical_element Morris water navigation task Metformin chemistry.chemical_compound chemistry Simvastatin medicine medicine.symptom business Sodium nitrite Diazepam medicine.drug
Zdroj:	International Journal of Pharmacy and Pharmaceutical Sciences. 10:18
ISSN:	0975-1491
DOI:	10.22159/ijpps.2018v10i6.19113
Popis:	Objective: To study the effect of metformin and simvastatin on diazepam-and sodium nitrite-induced anterograde amnesia in male Swiss albino mice.Methods: A total of 56 healthy male Swiss albino mice weighing 20–30 g were included in the study Mice were divided into seven groups (n=8) and received a specific dosage of drugs including metformin and simvastatin. Anterograde amnesia was induced by diazepam and sodium nitrite. Morris water maze paradigm was used to study amnesia in which the mice were trained to locate a hidden platform by releasing them into the opaque water for four times a day for four consecutive days. The acquisition of this task was evaluated by measuring escape latency time on all the days of study and by measuring the index of retrieval on day 5 of the study. These observations were compared among the test groups and drug-induced amnesia groups. The time was expressed as mean±standard error of the mean.Results: Significant reduction in the mean escape latency time (25.25 ± 5.09 s) and index of retrieval (52.38 ± 3.55 s) was observed in groups administered with sodium nitrite and metformin (p
Databáze:	OpenAIRE
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