Gastrointestinal transit, absorption and tissue retention of 51chromium in control and streptozotocin-induced diabetic rats
| Autor: | Barbara J. Stoecker, Bernice Adeleye |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Chemistry Endocrinology Diabetes and Metabolism Stomach Gastrointestinal transit Absorption (skin) Urine medicine.disease Streptozotocin Small intestine Cecum Endocrinology medicine.anatomical_structure Internal medicine Diabetes mellitus medicine medicine.drug |
| Zdroj: | Nutrition Research. 16:1191-1197 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/0271-5317(96)00123-6 |
| Popis: | Gastrointestinal transit, absorption, tissue retention and urinary excretion of 51 Cr from 51 CrCl 3 were investigated in control and streptozotocin (STZ)-induced diabetic rats. Animals were held a minimum of six weeks after STZ injection before the experiment. After an overnight fast, animals were dosed orally with 10 μCi of 51 CrCl 3 and sacrificed 2 hr thereafter. Radioactive chromium was counted in selected organs, blood, urine, segmented small intestine, and digested stomach, colon, and cecum. Results indicated that the absorption of 51 Cr from 51 CrCl 3 was low in both treatment groups. The gastroinestinal transit of 51 Cr was slower in diabetic than control rats, but blood concentrations, tissue retention and urinary excretion of 51 Cr were not significantly influenced by the diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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