Liposomes: The Long-term Stability and the Topical Effect to the Skin
| Autor: | Naoto Oku, Kazunori Iwanaga, Kumi Arakane, Noboru Naito, Shinji Yamashita, Kimie Hayashi |
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| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Journal of Society of Cosmetic Chemists of Japan. 27:216-226 |
| ISSN: | 1884-4146 0387-5253 |
| DOI: | 10.5107/sccj.27.216 |
| Popis: | The long-term stability of liposomes prepared from hydrogenated phosphatidylcholine was investigated in order to utilize liposomes in cosmetics.When incompletely hydrogenated soya phosphatidylcholine (IH-Soya PC) liposomes were stored at 40°C, pH decrease and corresponding change of liposomal appearance were observed. It was found that pH decrease was induced by the peroxidation of the residual unsaturated fatty acyl chains in IH-Soya PC. The liposomes composed of completely hydrogenated soya phosphatidylcholine (CH-Soya PC), whose appearance, pH and particle size did not change at wide-range thermal conditions, could maintain the trapped, water-soluble materials inside themselves for a long time. Furthermore, we examined the decomposition of PC during storage and observed that PC was drastically hydrolyzed by incorporating dicetylphosphate, a negatively charged lipid, into liposomes.On the basis of all the results, we finally succeeded in developing a stable liposomal formula.To investigate the potential of these liposomes as a delivery system in topical formulations, the percutaneous absorption of liposomes with radioactively labelled mannitol was studied in comparison with percutaneous absorption without liposomes. The [3H]-mannitol disposition studies indicated that the liposomal form produced significantly higher [3H]-mannitol accumulation in the skin. It was confirmed that the liposomal encapsulation favorably altered drug disposition when topically applied on the skin, a finding which led to the development of cosmetics with a long-lasting topical effect on the skin. |
| Databáze: | OpenAIRE |
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