Synthetic Studies on Suberosin and Osthol

Autor:	Iwao Morita, Eisuke Seto, Masao Murayama, Maehara Mitsuhiro, Takashi Okubo, Itsuo Dobashi
Rok vydání:	1972
Předmět:	chemistry.chemical_classification Metal salts Salt (chemistry) General Chemistry General Medicine Medicinal chemistry chemistry.chemical_compound chemistry Group (periodic table) Bromide Drug Discovery Organic chemistry Benzene Osthol
Zdroj:	Chemical and Pharmaceutical Bulletin. 20:741-746
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.20.741
Popis:	Alternative syntheses of Suberosin (V) as well as Osthol (I) have been described. When the metal salts of 2-hydroxy-4-methoxybenzaldehyde (XI), such as Li, Na, K, Ca and Ti salt, were treated with γ, γ-dimethylallyl bromide in benzene and water, the four compounds, 3-γ, γ-dimethylallyl-2-hydroxy-4-methoxybenzaldehyde (IV), 5-γ, γ-dimethylally1- 2-hydroxy-4-methoxybenzaldehyde (VIII), 2-γ, γ-dimethylallyloxy-4-methoxybenzaldehyde (IX) and 2-γ, γ-dimethylallyl-5-methoxyphenol (X) were obtained.Furthermore, IX was converted to VIII by the thermal rearrangement of the γ, γ-dimethylallyl group.
Databáze:	OpenAIRE
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