| Popis: |
Differences in cerebellar structure, function, and connectivity are well documented in autism spectrum disorder, and developmental cerebellar damage significantly elevates the risk for an autism diagnosis. Here we discuss the evidence for specific regional cerebellar disruption in autism, with a broader consideration of the impact of these regional differences on the modulation of cerebro-cerebellar circuits supporting autism-relevant behaviors. Further, we consider whether cerebellar contributions to these networks could disrupt predictive processing in autism, leading to the range of behavioral and neural patterns that characterize this complex neurodevelopmental disorder. Finally, we propose that the cerebellum could offer a potential therapeutic target for modulating autism-relevant circuits and behaviors. |
