Rapid Access to Functionalized γ-Lactams through Copper-Catalyzed Oxidative Cyclization of Diynes

Autor:	Wen-Bo Shen, Li-Xia Xie, Ting-Ting Zhang, Kua-Fei Wei, Guang-Xin Ru, Xiu-Hong Zhu
Rok vydání:	2022
Předmět:	Organic Chemistry
Zdroj:	Synlett. 34:149-152
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-1957-4104
Popis:	An efficient copper-catalyzed oxidative cyclization of diynes is described. A range of functionalized γ-lactams can be readily constructed by using this protocol. This copper-catalyzed oxidative process proceeds through an alkyne oxidation, carbene/alkyne metathesis, and donor–donor carbene oxidation sequence. The use of readily available substrates, high flexibility, a simple procedure, and mild reaction conditions render the procedure a viable alternative for the preparation of functionalized γ-lactams.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::75d91acaf7bbb2762dfa19e280a3f161 https://doi.org/10.1055/a-1957-4104 Zobrazit plný text záznamu