| Autor: |
L. Ignatowitz, J. H. Freed, P. Marrack, J. W. Kappler, J. McComarck, P. Hugo, J. Callahan |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Progress in Immunology Vol. VIII ISBN: 9783642514814 |
| DOI: |
10.1007/978-3-642-51479-1_8 |
| Popis: |
T cell receptors for antigen bound to Major histocompatibility complex proteins (MHC) are made up of a number of different variable elements, Vα, Jα, V² and so on. Although any given mouse or man can probably make at least 1010 different versions of these receptors it is certain that not all possible combinations are expressed in any given animal. In part the selection is limited by the collection of germ line genes for the variable elements available in that animal. For example, some mice have a large deletion at their Vβ locus and consequently can make 50% or less of all receptors possible in animals which have an intact β locus. Since somatic mutation does not occur for αβ T cell receptor genes, in theory deletions of this type could severely limit the ability of the T cells in such animals to recognize particular antigens. This does not usually seem to be the case, however. The T cell response to most antigen/MHC complexes is so degenerate that in fact it is quite difficult to demonstrate “holes” in the T cell repertoire due to problems of this type, although it can be done. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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