Endogenous Retrovirus Erv-3 Is Not Implicated in Rheumatoid Arthritis But May Provide a Biomarker for Osteoarthritis: Table 1

Autor:	Simon J. Bowman, Paul N. Nelson, Alan M. Nevill, Hora Davari-Ejtehadi
Rok vydání:	2010
Předmět:	Autoimmune disease business.industry Immunology Arthritis Osteoarthritis medicine.disease Peripheral blood mononuclear cell medicine.anatomical_structure Rheumatology Rheumatoid arthritis Immunology and Allergy Medicine Synovial fluid Biomarker (medicine) Synovial membrane business
Zdroj:	The Journal of Rheumatology. 37:473-473
ISSN:	1499-2752 0315-162X
DOI:	10.3899/jrheum.090735
Popis:	Rheumatoid arthritis (RA) is an autoimmune disease with chronic inflammation of the synovial membrane culminating in the destruction of cartilage and bone. The etiology is unknown, although possible causes include viral triggers1. The latter may include human endogenous retroviral (HERV) families: HERV-K, HERV-L, ERV-9, and ERV-32,3. We have reported a novel reverse transcriptase polymerase chain reaction (RT-PCR) system to identify HERV-K10 and identified significantly high levels of messenger RNA in the peripheral blood (and synovial fluid) of patients with RA compared to osteoarthritis (OA) and healthy controls4. In our study, we modified the RT-PCR system to analyze ERV-3 expression in these patients. Peripheral blood mononuclear cells (PBMC) from 20 RA patients who fulfilled American Rheumatism Association criteria were used to extract … Address correspondence to Dr. P. Nelson; E-mail: p.n.nelson{at}wlv.ac.uk
Databáze:	OpenAIRE
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