Synthese, resolution Optique et Radiolyse d'Acides amines A haute Activite Specifique: L-Ornithine (3H-3,4,5,5). L-Arginine (3H-3,4,5,5). Acide dl-Glutamique (3H-3,4) ET Acide dl-Glutamique (3H-3,4,4)
| Autor: | D. Ego, Louis Pichat, J. P. Beaucourt |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
chemistry.chemical_classification
Tris Stereochemistry Organic Chemistry Reversed-phase chromatography Ornithine Biochemistry Medicinal chemistry Analytical Chemistry Amino acid chemistry.chemical_compound Hydrolysis chemistry Drug Discovery Radiolysis Radiology Nuclear Medicine and imaging Enantiomer Triphenylphosphine Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 23:553-564 |
| ISSN: | 0362-4803 |
| Popis: | Ethyl 2-acetylamino-2-carbethoxy-4-cyano-3-butene oate : 3 was prepared by condensation of trans-1-bromo-2-cyanoethylene : 2 with ethyl sodio acetamidomalonate. 3 was catalytically reduced with tritium followed by hydrolysis giving rise to (3,4,5,5-3H) DL ornithine 5 spec. act. 103 Ci/mM. L-ornithine 6 was isolated by preparative reversed phase HPLC on a chiral phase. From 5,(3,4,5,5-3H) DL arginine spec. activity : 90 Ci/mM was prepared by guanidation and the l (+) enantiomer isolated by preparative HPLC. Selective catalytic tritiation of 3 in presence of tris (triphenylphosphine) Rh followed by hydrolysis gave [3,4-3H] DL-glutamic acid spec. activit 60 Ci/mM. [3,4,4-3H] DL-glutamic acid spec. activity 90 Ci/mM was also obtained by catalytic tritiation of compound 15 followed by hydrolysis. 3H–NMR analyses were carried out in each ease. Observations on the self radiolysis under various storage conditions are reported. |
| Databáze: | OpenAIRE |
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