Epidemiological investigation of recurrent outbreaks of haemolytic uraemic syndrome caused by Shiga toxin-producingEscherichia coliserotype O55:H7 in England, 2014–2018
| Autor: | Timothy J. Dallman, Bhavita Vishram, L Ahyow, Claire Jenkins, K J Carroll, F. Jorgensen, Sooria Balasegaram, Amy Mikhail, C Sawyer, Lisa Byrne, Q Vahora, Gauri Godbole |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Serotype medicine.medical_specialty Epidemiology business.industry Transmission (medicine) Public health 030106 microbiology Outbreak Virology law.invention 03 medical and health sciences 030104 developmental biology Infectious Diseases law medicine Haemolytic-uraemic syndrome business Pathogen Polymerase chain reaction |
| Zdroj: | Epidemiology and Infection. 149 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268821000844 |
| Popis: | Recurrent outbreaks of haemolytic uraemic syndrome (HUS) caused by Shiga toxin-producingEscherichia coli(STEC) serotype O55:H7 occurred in England between 2014 and 2018. We reviewed the epidemiological evidence to identify potential source(s) and transmission routes of the pathogen, and to assess the on-going risk to public health. Over the 5-year period, there were 43 confirmed and three probable cases of STEC O55:H7. The median age of cases was 4 years old (range 6 months to 69 years old) and over half of all cases were female (28/46, 61%). There were 36/46 (78.3%) symptomatic cases, and over half of all cases developed HUS (25/46, 54%), including two fatal cases. No common food or environmental exposures were identified, although the majority of cases lived in rural or semi-rural environments and reported contact with both wild and domestic animals. This investigation informed policy on the clinical and public health management of HUS caused by STEC other than serotype O157:H7 (non-O157 STEC) in England, including comprehensive testing of all household contacts and household pets and more widespread use of polymerase chain reaction assays for the rapid diagnosis of STEC-HUS. |
| Databáze: | OpenAIRE |
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