| Popis: |
OBJECTIVE: The present study aims to analyse the prevalence of Cerebral Amyloid Angiopathy (CAA) among the various neuro surgical tissue samples, to study the histomorphological changes of CAA in neural tissue and to analyse their association with increasing age & neurological disorders. METHOD: Retrospective analysis and review of all neurosurgical specimens received during the period from 2009 to 2019 was carried out. Review of the clinical details including radiological images, and review of paraffin sections was conducted by two pathologists after appropriate special stains like Congo red. RESULTS: Among the 301 cases studied, 14(4.65%) had evidence of CAA. Of the 14, 6(42.86%) were males and 8(57.14%) were female All of the 14(10.77%) cases were above the age group of 50 years. In the more than 50 age group, this contributes to 9.68% of males and 11.76% of females. CONCLUSIONS: CAA is found to be a diagnosis more common in the older age group (>50 years) and with a female preponderance. Familiarising & understanding the pathological sequence and morphological changes of CAA, will help in diagnosis, formulating treatment options for the better clinical outcome of CAA patients |
