| Autor: |
Lee, Y. Z., Lu, J., Zhou, O. Z., Maeda, N., Wait, J. M. S., Tomita, H., Burk, L. M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| DOI: |
10.17615/b0zr-2r14 |
| Popis: |
BackgroundWe performed in vivo micro‐computed tomography (micro‐CT) imaging using a novel carbon nanotube (CNT)–based x‐ray source to detect calcification in the aortic arch of apolipoprotein E (apoE)–null mice.Methods and ResultsWe measured calcification volume of aortic arch plaques using CNT‐based micro‐CT in 16‐ to 18‐month‐old males on 129S6/SvEvTac and C57BL/6J genetic backgrounds (129‐apoE KO and B6‐apoE KO). Cardiac and respiratory gated images were acquired in each mouse under anesthesia. Images obtained using a CNT micro‐CT had less motion blur and better spatial resolution for aortic calcification than those using conventional micro‐CT, evaluated by edge sharpness (slope of the normalized attenuation units, 1.6±0.3 versus 0.8±0.2) and contrast‐to‐noise ratio of the calcifications (118±34 versus 10±2); both P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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