| Autor: |
Shengdian Wang, Shangen Zheng, Guomei Kou, Wanbing Liu, Yaqiong Zheng, Lei Liu, Yan Liu, Liping Cai |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Blood and Genomics. 5:41-47 |
| ISSN: |
2519-7916 |
| DOI: |
10.46701/bg.2021012021102 |
| Popis: |
This paper aimed to analyze antibody responses to SARS-CoV-2 in various populations. Two hundred and six COVID-19 patients, 46 convalescent patients, and 270 healthy population were enrolled. Antibodies against nucleocapsid protein (N) and spike protein's receptor-binding domain (RBD), and neutralizing antibody were detected. The results demonstrated both anti-N and anti-RBD antibodies could be detected in about 80% of COVID-19 patients and 90% of convalescent patients, while no antibodies could be detected in some convalescents and patients even after 14 days post-onset of symptoms. The level of anti-RBD antibody strongly correlated with the neutralizing activity of sera from these two cohorts. The titer of neutralizing antibody was lower in convalescents than that in active COVID-19 patients. In addition, the titer of neutralizing antibody was less than 1:80 in none of the severe COVID-19 patients, 18.8% in non-severe COVID-19 patients, and 32.6% in convalescents. The study suggests that the level of anti-RBD antibody is closely related to neutralization activity in COVID-19 patients and convalescents. Some SARS-CoV-2-infected cases trigger a weak antiviral immune response, and the level of neutralizing antibody may have a faster decay rate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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