The Chaenomeles sinensis Extract has the Potential to Exhibit Antioxidant Activity or Attenuate Liver Damage
| Autor: | Seung-Il Jeong, Kang-Yeol Yu, Ji-Young Kim, Young-Ji Choi, Young-Moo Choo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Antioxidant biology Traditional medicine Chemistry medicine.medical_treatment Plant Science General Medicine 030204 cardiovascular system & hematology biology.organism_classification 03 medical and health sciences 0302 clinical medicine Complementary and alternative medicine Drug Discovery medicine 030211 gastroenterology & hepatology Liver damage Chaenomeles |
| Zdroj: | Natural Product Communications. 13:1934578X1801300 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | Even though Chaenomeles sinensis is extensively used as a medicinal product to cure coughs, little is known about the biomedical efficacies of C. sinensis. In this study, we report the novel efficacy of C. sinensis extract ( Cs-E01). Our 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide anion scavenging assays revealed that Cs-E01 exhibits strong antioxidant activity in vitro. In addition, Cs-E01 played a negative role in transforming growth factor (TGF-β1)-induced gene expression in LX-2 cells, suggesting that Cs-E01 is related to the cellular pathway suppressing liver damage. |
| Databáze: | OpenAIRE |
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