Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry

Autor:	Xueying Kang, Haishun Ye, Shanshan Liu, Xiaoqiang Tu, Jiqin Zhu, Hongyan Sun, Long Yi
Rok vydání:	2023
Předmět:	Materials Chemistry Metals and Alloys Ceramics and Composites General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Chemical Communications. 59:4233-4236
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d3cc00684k
Popis:	Cysteine esters and amides spontaneously degrade under physiological conditions to generate H2S. This discovery not only provides new insights into fundamental science issues, but also inspires a class of tunable cleavage motifs for prodrug design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::75a17321b97b98764c925023b0b946e0 https://doi.org/10.1039/d3cc00684k Zobrazit plný text záznamu