| Autor: |
Giannakopoulou Erofili, Yan Zi, Ataide Carneiro de Paula Gonzaga Ana Luiza, Hayden Matthew, Zhong Hui, Mastinu Andrea, Andrade Palmeira Vitória, Qi Wenqing, Ribaudo Giovanni, Memo Maurizio, Ahmadi Fatemeh, Ferec Claude, Masson Emmanuelle, Ramezani Zahra, Lin Jin-Huan, Rahbar Nadereh, Liao Zhuan, Mlinarić-Majerski Kata, Nourani Masoumeh, Ongaro Alberto, Anna Bonini Sara, Braga Costa Larissa, Li Gang, Cristina Simões-e-Silva Ana, Li Wei, Zhao Jinwu, Tang Hui-Fang, Li Xiaoxun, Felipe Silva Ribeiro Thomas, Wang Qing, Zoidis Grigoris, Chen Jianjun, C. Taylor Martin, Pardali Vasiliki, Myrianthopoulos Vassilios, Zhu Yanbo, Zhang Newby Bi-min, Šekutor Marina, Gianoncelli Alessandra, N. Cooper David, Luo Meihua, M. Kelly John, Chen Jian-Min, Emília de Sá Rodrigues Karla, Balourdas Dimitrios-Ilias, Kai Yin, Tang Ze |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Current Pharmaceutical Analysis. 17:668-678 |
| ISSN: |
1573-4129 |
| DOI: |
10.2174/1573412916666200210150914 |
| Popis: |
Background:Sample preparation is one of the most challenging phases in pharmaceutical analysis, especially in biological matrices, affecting the whole analytical methodology.Objective:In this study, a new Ca(II)/Cu(II)/alginate/CuO Nanoparticles Hydrogel Fiber (CCACHF) was synthesized through a simple, green procedure and applied for fiber micro solid-phase extraction (FMSPE) of diazepam (DIZ) and oxazepam (OXZ) as model drugs prior to high-performance liquid chromatography-UV detection (HPLC-UV).Methods:Composition and morphology of the prepared fiber were characterized and the effect of main parameters on the fiber fabrication and extraction efficiency have been studied and optimized.Results:In optimal conditions, calibration curves were linear, ranging between 0.1–500 μg L−1with regression coefficients of 0.9938 and 0.9968. Limit of Detection (LOD) (S/N=3) and Limit of Quantification (LOQ) (S/N=10) of the technique for DIZ and OXZ were 0.03 to 0.1 μg L−1. Within-day and between-day Relative Standard Deviations (RSDs) for DIZ and OXZ were 6.0–12.5% and 3.3–9.4%, respectively.Conclusion:The fabricated adsorbent has been substantially employed to the extraction of selected benzo-diazepines (BZDs) from human serum real specimens and the obtained recoveries were also satisfactory (82.1-109.7%). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
