ChemInform Abstract: Reaction of 1,2-Anhydro-3,4:5,6-di-O-isopropylidene-1-C-nitro-D-mannitol with Potassium Hydrogenfluoride in Ethylene Glycol: A Synthesis of 2-Deoxy-2-fluoro-D-glucose

Autor:	Bogdan Doboszewski, Milton M. Perlmutter, Walter A. Szarek, George W. Hay
Rok vydání:	1987
Předmět:	Solvent chemistry.chemical_classification chemistry.chemical_compound chemistry D-Glucose Potassium hydrogenfluoride Nitro Anhydrous Epimer General Medicine Medicinal chemistry Aldehyde Ethylene glycol
Zdroj:	ChemInform. 18
ISSN:	0931-7597
DOI:	10.1002/chin.198724317
Popis:	The reaction of 1,2-anhydro-3,4:5,6-di-O-isopropylidene-1-C-nitro-d-mannitol (2) with potassium hydrogenfluoride in ethylene glycol under anhydrous conditions provides a route to 2-deoxy-2-fluoro-d-glucose, the 18F-labeled analog of which is an important radiopharmaceutical of use in medical imaging. The reaction is accompanied to a minor extent by epimerization at C-2 of the initially formed fluoro aldehyde and also results in an attack by solvent at C-2 in 2.
Databáze:	OpenAIRE
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