Expression of β-Catenin in Hepatocellular Carcinoma
| Autor: | R. Cornea, Sorina Tăban, Norina Basa, Anca Tudor, Adrian Goldis, Daniela Lazăr, Melania Ardelean, Amadeus Dobrescu, Ramona Goldis, Robert Alexandru Barna, Marioara Cornianu, Alexandra Faur |
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| Rok vydání: | 2001 |
| Předmět: |
Process equipment
Chemistry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering General Chemistry General Medicine medicine.disease digestive system diseases General Biochemistry Genetics and Molecular Biology Petrochemistry Hepatocellular carcinoma Catenin Materials Chemistry medicine Cancer research General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Revista de Chimie. 71:116-125 |
| ISSN: | 2668-8212 0034-7752 |
| Popis: | Alteration of β-catenin expression is involved in the development and evolution of hepatocellular carcinoma (HCC); β-catenin is able to influence tumor cell proliferation. We analyzed the immunohistochemical (IHC) expression of β-catenin on a group of 32 patients diagnosed with HCC using the anti-β-catenin monoclonal antibody (clone E247). We correlated the expression of β-catenin with the proliferation index of Ki-67 (PI Ki-67), the mitotic index (MI) and other clinical and pathological features. We observed an altered β-catenin expression in 58.38% of all HCC cases. This expression was insignificantly correlated with tumor size (]5 cm) (p = 0.683), histological grade G1-G2 (p = 0.307), vascular invasion (p = 0.299) and advanced pT stage (p = 0.453); we obtained a significantly higher MI in HCC with altered β-catenin expression (p = 0.018), as compared to HCC without overexpression (1.66 � 1.37) (p = 0.038) and a PI Ki-67 of 22.49 � 20.1 and 28.24 � 18.2, respectively in tumors with altered β-catenin expression with insignificant differences compared to HCC without overexpression (25.95 � 15.2) (p = 0.682 and p = 0.731, respectively). According to the results we obtained, aberrant β-catenin expression in HCC was correlated with a high mitotic index, therefore playing an important role in tumor progression by stimulating tumor cell proliferation; non-nuclear β-catenin overexpression can have a pathological significance in HCC, especially in cases of HCC associated with hepatitis B virus (HBV) infection. |
| Databáze: | OpenAIRE |
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