Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin
| Autor: | Subash Vetri Selvi, Shen-Ming Chen, Hsieh-Chih Tsai, Adhimoorthy Prasannan, Juin-Yih Lai, Adhisankar Vadivelmurugan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Reproducibility Nanochemistry Nanoparticle 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Blood serum chemistry Cystamine Electrode 0210 nano-technology Selectivity Nuclear chemistry |
| Zdroj: | Microchimica Acta. 188 |
| ISSN: | 1436-5073 0026-3672 |
| DOI: | 10.1007/s00604-020-04642-8 |
| Popis: | Two-dimensional (2D) MoS2core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with L-glutathione and cystamine (L-GSH–MoS2–CYS) using ultrasonic frequency of 20–25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1–78.3 and 98.3–1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM−1 cm−2 was acquired at 0.48 V. The fabricated L-GSH–MoS2–CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated L-GSH–MoS2–CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink