Effect of Astaxanthin Supplementation on Psychophysiological Heart-Brain Axis Dynamics in Healthy Subjects
| Autor: | Don Hantla, Shawn M. Talbott, Christian Artaria, Yanmei Li, Lixin Ding, Bob Capelli |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Haematococcus pluvialis Nutrition and Dietetics biology medicine.drug_class Medicine (miscellaneous) Profile of mood states biology.organism_classification Placebo medicine.disease_cause Biochemistry Anxiolytic chemistry.chemical_compound Endocrinology chemistry Astaxanthin Internal medicine Heart rate medicine Anaerobic exercise Oxidative stress Food Science |
| Zdroj: | Functional Foods in Health and Disease. 9:521 |
| ISSN: | 2160-3855 2378-7007 |
| Popis: | Objective: Marine microalgae is the predominant source of natural astaxanthin (NAX), a red-orange carotenoid with powerful antioxidant and anti-inflammatory properties. Previous studies suggest that NAX supplementation improves antioxidant capacity and reduces oxidative stress, while also enhancing fat utilization, exercise endurance, cardiovascular function, and neurological parameters. The purpose of this study was to assess the effects of NAX on the psychophysiological “heart-brain-axis” while nutrition (astaxanthin) may impact physiology (cardiovascular function) and psychology (mood state) in a coordinated manner.Methods: Using a double-blind parallel design, 28 healthy subjects (male=14, female=14, age=42) were supplemented for 8 weeks with NAX (12mg/day Haematococcus pluvialis algal extract) or a matching placebo. Before and after supplementation, subjects performed a cardiovascular stress test (VO2max) and completed a validated Profile of Mood States (POMS) survey to assess global mood state (GM) and related subscales: Vigor (V), Tension (T), Depression (D), Anger (A), Fatigue (F), and Confusion (C).Results: Subjects in the NAX group showed a significant ~10% lower average heart rate at submaximal exercise intensities compared to those in the placebo group (aerobic threshold, AeT; NAX 130+17 v. PL 145+14; and anaerobic threshold, AT; NAX 139+20 v. PL 154+11, p |
| Databáze: | OpenAIRE |
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