Fluorine substituent effects (on bioactivity)

Autor:	Bruce E. Smart
Rok vydání:	2001
Předmět:	Steric effects Organic Chemistry Substituent chemistry.chemical_element Biological activity Biochemistry Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Lipophilicity Fluorine Environmental Chemistry Molecule Physical and Theoretical Chemistry Solubility Absorption (chemistry)
Zdroj:	Journal of Fluorine Chemistry. 109:3-11
ISSN:	0022-1139
Popis:	The characteristic effects of fluorine and fluoroalkyl substituents on the physico-chemical properties of molecules that are important to biological activity of fluorinated compounds are highlighted. The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is described. The current perspectives on fluorine steric interactions and the controversial role of hydrogen-bonding involving the CF bond are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7583500e6e6dc28478532d3992ab5a51 https://doi.org/10.1016/s0022-1139(01)00375-x Zobrazit plný text záznamu Full Text from ScienceDirect