Fluorine substituent effects (on bioactivity)
Autor: | Bruce E. Smart |
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Rok vydání: | 2001 |
Předmět: |
Steric effects
Organic Chemistry Substituent chemistry.chemical_element Biological activity Biochemistry Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Lipophilicity Fluorine Environmental Chemistry Molecule Physical and Theoretical Chemistry Solubility Absorption (chemistry) |
Zdroj: | Journal of Fluorine Chemistry. 109:3-11 |
ISSN: | 0022-1139 |
Popis: | The characteristic effects of fluorine and fluoroalkyl substituents on the physico-chemical properties of molecules that are important to biological activity of fluorinated compounds are highlighted. The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is described. The current perspectives on fluorine steric interactions and the controversial role of hydrogen-bonding involving the CF bond are discussed. |
Databáze: | OpenAIRE |
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