The Effects of Thymoquinone on Nitric Oxide and Superoxide Dismutase Levels in a Rat Model of Diazinon-induced Brain Damage
| Autor: | Irfan Altuntas, Nigar Yilmaz, Ibrahim Haki Cigerci, Hatice Topal, Esin Sakalli Cetin, Yaşar Topal, Hamdi Sözen, Halil Beydilli |
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| Rok vydání: | 2015 |
| Předmět: |
Cultural Studies
Diazinon Antioxidant biology medicine.medical_treatment Organophosphate Medicine (miscellaneous) Brain damage Pharmacology medicine.disease_cause Nitric oxide Toxicology Superoxide dismutase chemistry.chemical_compound Complementary and alternative medicine chemistry Anthropology medicine biology.protein medicine.symptom Thymoquinone Oxidative stress |
| Zdroj: | Studies on Ethno-Medicine. 9:191-195 |
| ISSN: | 0973-5070 |
| Popis: | Diazinon (DI) is an organophosphate. Thymoquinone (TQ) is produced from Nigella sativa. This study was a biochemical investigation of the protective properties of TQ as a supportive treatment in brain damage caused by diazinon. Rats were divided into four groups of eight, as follows: Group 1, control; group 2, DI; group 3, DI + TQ; and group 4, TQ. Groups 2 and 3 received DI. Groups 3 and 4 received TQ. In group 2, NO levels were higher and SOD levels were lower compared to the control group. In groups 3 and 4, NO levels were lower and SOD levels were higher than in either the control or group 2. In group 4, DNA damage was lower than in group 2, but the difference between groups 2 and 3 was not significant. The results suggest that TQ, because of its antioxidant properties, can be used to treat oxidative stress caused by DI intoxication. |
| Databáze: | OpenAIRE |
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