Palladium-promoted asymetric oxyamination of alkenes application to the synthesis of optically active aryloxypropanolamines
| Autor: | A. Solladié-Cavallo, Styrbjörn Byström, Jan-E. Bäckvall, Eva E. Björkman |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
chemistry.chemical_classification
genetic structures Ligand Alkene Aryl Organic Chemistry chemistry.chemical_element Optically active Biochemistry Combinatorial chemistry eye diseases chemistry.chemical_compound chemistry Nucleophile Yield (chemistry) Drug Discovery Organic chemistry Amine gas treating sense organs Palladium |
| Zdroj: | Tetrahedron Letters. 23:943-946 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(00)86989-0 |
| Popis: | Palladium-promoted oxyamination of some alkene using optically active N-methyl-α☎enylethylamine as amine nucleophile, or using optically active N,N-dimethyl-α-phenylethylamine as ligand, produces optically active aminoalcohol derivatives in an optically yield of 3–60%. Oxyamination of aryl ethers gives optically active 1-amino-3-aryloxy-propan-2-ol derivatives, which are important β-blockers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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