ChemInform Abstract: Synthesis of N-Acyl-5-aminopenta-2,4-dienals via Base-Induced Ring-Opening of N-Acylated Furfurylamines: Scope and Limitations

Autor:	Cecile Ouairy, Christian Marazano, David Crich, Patrick Michel, Bernard Delpech
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Deprotonation chemistry Scope (project management) Base (chemistry) Stereochemistry Furan Moiety General Medicine Ring (chemistry) Carbonyl group Isomerization
Zdroj:	ChemInform. 41
ISSN:	0931-7597
Popis:	N-Acylation of furfurylamines provided 1, which on double deprotonation with LDA led to the formation of N-acyl-5-aminopenta-2,4-dienals 2 via an isomerization involving opening of the furan ring. The scope and limitations of the procedure were examined by considering the influence of substituents on the carbonyl group and also on the heterocycle moiety. The efficacy of the reaction was shown to be very dependent on the nature of these groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::757b63bc9b743cd24635bce2d7f171fc https://doi.org/10.1002/chin.201040050 Zobrazit plný text záznamu Plný text