Influence of different ointment bases on the antimicrobial activity of arenarin

Autor: A. K. Negrash, Salo Dp, Khristenko La, Pertsev Im
Rok vydání: 1977
Předmět:
Zdroj: Pharmaceutical Chemistry Journal. 11:690-694
ISSN: 1573-9031
0091-150X
DOI: 10.1007/bf00780833
Popis: B-Oxobutyrate (VI) of the u Isomer of 1,2,5-Trimethyl-4-phenyl-4-piPeridol. Into reaction were brought 5 g (0.023 mole) of y-I, 7.2 g (0.071 mole) of triethylamine, 1.6 g (0.02 mole) of acetyl chloride, and 80 ml of benzene; the reaction was carried out as before. On chromatographic separation of the reaction products on aluminum oxide (using petroleum ether as eluent), 0.2 (7%) of the dehydration product VII, 0.5 g (10%) of ester VI, and 1.2 g of y-I were successively isolated. The hydrochloride of ester VI had mp 167-170 ~ (from acetone). IR spectrum: bands at 1745 and 1735 cm -* , belonging to 8'ketoester group. Found, %: C1 10.7; N 4.2. C~sH2sNO3.HCI. Calculated, %: C1 10.5; N 4.1. Picrate of ester VI, mp 155-155.5 ~ (from alcohol). Found, %: N 10.8. C18H25NO3.C~H3N307. Calculated, %: N 10.5.
Databáze: OpenAIRE
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