| Autor: |
L. O. Merola, Jin H. Kinoshita, H. N. Fukui |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Progress of Lens Biochemistry Research ISBN: 9789061931485 |
| DOI: |
10.1007/978-94-010-1571-4_17 |
| Popis: |
The effects of -SH oxidants, iodosobenzoate and diamide, on lens membrane function were studied. Both oxidants decrease the ability of the rabbit lens to concentrate rubidium (Rb) ions. Diamide is more effective than iodosobenzoate. Under the conditions used, diamide affects both the uptake and the leak out processes. While iodosobenzoate affects Rb uptake but does not affect the leak out process to a significant extent. These effects are observed in the absence of glucose. The presence of glucose in the medium abolishes the effects of the -SH oxidants. A marked increase in the oxidation of carbon one atom of glucose is observed in the lens incubated with diamide suggesting the stimulation of the pentose shunt mechanism to provide TPNH necessary to maintain the sulfhydryl groups in the reduced form. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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