Synthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid
| Autor: | I. M. Nazaryan, A. G. Hakobyan, N. S. Minasyan, A. A. Aghekyan, R. G. Paronikyan, R. E. Markaryan, Zh. S. Arustamyan |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Amino esters 010405 organic chemistry Carboxylic acid medicine.medical_treatment Organic Chemistry 01 natural sciences 0104 chemical sciences Carbonyl chloride chemistry.chemical_compound Anticonvulsant chemistry medicine Organic chemistry Cyclopentane Alkaline hydrolysis |
| Zdroj: | Russian Journal of Organic Chemistry. 55:796-799 |
| ISSN: | 1608-3393 1070-4280 |
| DOI: | 10.1134/s1070428019060095 |
| Popis: | Alkaline hydrolysis of 1-(2,3-dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carbonitrile gave the corresponding carboxylic acid which was converted to carbonyl chloride, and the latter reacted with N, N-di-alkylalkane-α,ω-diamines and dialkylaminoalkanols to afford new amino amides and amino esters which were isolated as hydrochlorides. Anticonvulsant activity of the synthesized compounds was studied. |
| Databáze: | OpenAIRE |
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