Constitutive Expression of phVEGF 165 After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia
| Autor: | Knud S. Christensen, Anne Arveschoug |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
business.industry Genetic enhancement Gene transfer Critical limb ischemia Walking time Surgery Vascular endothelial growth factor Neovascularization chemistry.chemical_compound chemistry Physiology (medical) Internal medicine medicine Cardiology In patient medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 99 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circ.99.22.2967/b |
| Popis: | To the Editor: Baumgartner et al1 reported a significant advance in angiogenic gene therapy. They induced collateral neovascularization in 10 critically ischemic limbs by injection of vascular endothelial growth factor (phVEGF165) into the muscles of the ischemic limbs. The effect of the therapy was demonstrated by a significant rise in ankle-brachial index, newly visible collateral blood vessels on the contrast angiogram, healing of the patients’ former ulcers, and improvement in pain-free walking time. The authors cautiously claim that such … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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