ChemInform Abstract: Discovery of 6-Benzyloxyquinolines as c-Met Selective Kinase Inhibitors
Autor: | Takaaki A. Fukami, Kwangseok Ko, Hiroshi Koyano, Hiroki Nishii, Takashi Chiba, Kenji Morikami, Hiroshi Sakamoto |
---|---|
Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 41 |
ISSN: | 1522-2667 0931-7597 |
Popis: | A novel quinoline derivative that selectively inhibits c-Met kinase was identified. The molecular design is based on a result of the analysis of a PF-2341066 (1)/c-Met cocrystal structure (PDB code: 2wgj). The kinase selectivity of the derivatives is discussed from the view point of the sequence homology of the kinases, the key interactions found in X-ray cocrystal structures, and the structure-activity relationship (SAR) obtained in this work. |
Databáze: | OpenAIRE |
Externí odkaz: |