Synthesis and antitumor activity of some 5α-steroid derivatives

Autor:	L. Sh. Amiranashvili, Maia Merlani, K. G. Mulkidzhanyan, A. R. Shelar
Rok vydání:	2008
Předmět:	Antitumor activity Chemistry medicine.medical_treatment Biological activity Plant Science General Chemistry Combinatorial chemistry General Biochemistry Genetics and Molecular Biology Steroid chemistry.chemical_compound Hydroxylamine Pyridine medicine Cancer cell lines
Zdroj:	Chemistry of Natural Compounds. 44:819-820
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-009-9206-4
Popis:	Recently we reported the synhesis and biological activity of some 5α-androstane derivatives that exhibit pronounced antitumor activity toward certain cancer cell lines [1]. In continuation of the search for highly effective compounds in this series, we synthesized new 5α-androstane and 5α-pregnane derivatives and studied their antitumor activity. Oximes (1-4) were prepared from the corresponding ketosteroids 3α-hydroxy-5α-pregn-16-en-20-one (5), 3α-hydroxy-5α-pregnan-20-one (6), 3α-hydroxy-5α-androst-9(11)-en-17-one (7), and androst-1,4-dien-3,17-dione (8) by reacting them with hydroxylamine in pyridine. The starting ketones (5-8) were synthesized beforehand by the literature method [2]. Aminonitrile 9 was synthesized as previously described [3].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7558d43e525307a3933920e38105cabe https://doi.org/10.1007/s10600-009-9206-4 Zobrazit plný text záznamu Plný text ve formátu PDF