[18F]FDG-PET Combined with MRI Elucidates the Pathophysiology of Traumatic Brain Injury in Rats
| Autor: | Reed Selwyn, Fiona Brabazon, Kimberly R. Byrnes, Colin M. Wilson, Sanjeev Mathur, Shalini Jaiswal, Sara Bermudez, Dinesh K Shukla |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Traumatic brain injury Hippocampus Poison control Corpus callosum medicine.disease Amygdala 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Positron emission tomography medicine Effective diffusion coefficient Neurology (clinical) business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 34:1074-1085 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Non-invasive measurements of brain metabolism using 18F-fluorodeoxyglucose (FDG) with positron emission tomography (PET) may provide important information about injury severity following traumatic brain injury (TBI). There is growing interest in the potential of combining functional PET imaging with anatomical and functional magnetic resonance imaging (MRI). This study aimed to investigate the effectiveness of combining clinically available FDG-PET with T2 and diffusion MR imaging, with a particular focus on inflammation and the influence of glial alterations after injury. Adult male Sprague Dawley rats underwent a moderate controlled cortical impact (CCI) injury followed by FDG-PET, MRI, and histological evaluation. FDG uptake showed significant alterations in the corpus callosum, hippocampus, and amygdala after TBI, demonstrating that a relatively “focal” CCI injury can result in global alterations. Analysis of MRI T2 intensity and apparent diffusion coefficient (ADC) also showed significant al... |
| Databáze: | OpenAIRE |
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