Influence of central neuronal histamine on the pituitary-adrenocortical activity stimulated by neurotransmitters

Autor:	Bugajski Aj, Borycz J, Jan Bugajski
Rok vydání:	1992
Předmět:	Pharmacology Agonist medicine.medical_specialty Carbachol medicine.drug_class GABAA receptor Immunology Mepyramine Toxicology chemistry.chemical_compound Endocrinology chemistry Muscimol Corticosterone Internal medicine Isoprenaline medicine Inverse agonist Pharmacology (medical) medicine.drug
Zdroj:	Agents and Actions. 36:C346-C349
ISSN:	1420-908X 0065-4299
DOI:	10.1007/bf01997370
Popis:	The effect of brain neuronal histramine and its receptors on monoaminergic stimulation of the hypothalamic-pituitary-adrenal (HPA) activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. Pretreatment with α-fluoromethylhistidine, (α-FMH) a histamine synthesis inhibitor, did not markedly affect the increase in serum corticosterone levels induced by intracerebroventricular (icv) injection of muscimol, a GABAA receptor agonist and noradrenaline, an α- and β-adrenergic agonist, and slightly diminished the corticosterone response to isoprenaline, a β-adrenergic agonist. α-FMH totally abolished the increase in serum corticosterone induced by carbachol, a cholinergic muscarinic receptor agonist and significantly diminished the rise in corticosterone levels induced by clonidine, an α2-adrenergic agent. Pretreatment with the histamine receptor antagonists mepyramine and cimetidine also considerably reduced the carbachol-induced corticosterone response and the response induced by clonidine.
Databáze:	OpenAIRE
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