The synthesis of labelled forms of cipemastat
| Autor: | G Maile, K. J. Prior, H. R. Wiltshire, J. Dhesi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Hydroxamic acid biology medicine.drug_class Chemistry Stereochemistry Organic Chemistry Carboxamide Biochemistry Chemical synthesis Analytical Chemistry chemistry.chemical_compound Enzyme Enzyme inhibitor Amide Drug Discovery medicine Cipemastat biology.protein Radiology Nuclear Medicine and imaging Glucuronide Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 44:149-164 |
| ISSN: | 1099-1344 0362-4803 |
| DOI: | 10.1002/jlcr.440 |
| Popis: | The development of the collagenase inhibitor, cipemastat (Ro 32-3555), required the synthesis of both carbon-14 labelled and deuteriated material for the measurement of the parent drug and drug-related material in biological fluids. In addition, labelled metabolites were needed for both in vitro metabolism and analytical studies. This paper describes the synthesis of labelled forms of cipemastat and its amide (Ro 32-4778) and glucuronide (Ro 32-6414) metabolites. Copyright © 2001 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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