A Flexible Strategy for Modular Synthesis of Curcuminoid‐BF 2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines
Autor: | Dawn Raja Somu, Kenneth K. Laali, Scott D. Bunge, Rodrigo Abonia, Esther C. Wang |
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Rok vydání: | 2020 |
Předmět: |
Pharmacology
010405 organic chemistry Organic Chemistry 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cell culture Apoptosis Drug Discovery Cancer research Molecular Medicine Curcuminoid General Pharmacology Toxicology and Pharmaceutics Cancer cell lines Human cancer |
Zdroj: | ChemMedChem. 15:354-362 |
ISSN: | 1860-7187 1860-7179 |
Popis: | A facile protocol that enables synthetic interconversion of CUR-BF2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines. |
Databáze: | OpenAIRE |
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