Propagation of Dengue Virus Strains in Unweaned Mice 1

Autor:	Edwin H. Lennette, Beatrice England, Gordon Meiklejohn
Rok vydání:	1952
Předmět:	Infectious Diseases Virology medicine New guinea Parasitology Dengue virus Biology medicine.disease medicine.disease_cause Neutralization Microbiology Dengue fever
Zdroj:	The American Journal of Tropical Medicine and Hygiene. 1:51-58
ISSN:	1476-1645 0002-9637
DOI:	10.4269/ajtmh.1952.1.51
Popis:	Summary 1. The New Guinea C and D strains were readily adapted to unweaned mice after a relatively small number of serial intracerebral passages. 2. Work with dengue virus may be greatly facilitated by using unweaned mice rather than older animals for isolation and passage, and, with certain strains, for neutralization tests. 3. The 5 strains of dengue virus studied behaved relatively uniformly in unweaned mice 2–6 days of age but differed sharply in their behavior in mice 3–4 weeks old. 4. Cross-neutralization tests in mice corroborated earlier observations that the New Guinea C and D strains are immunologically different from the Hawaiian and Mochizuki strains.
Databáze:	OpenAIRE
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