SYNTHESIS, CHARACTERIZATION, AND ANTICANCER ACTIVITY OF SOME NOVEL ACRIDINE DERIVATIVES

Autor:	Swetha Padigela, Rajendra Prasad Vvs, Bhagavan Raju Rm
Rok vydání:	2020
Předmět:	Pharmacology Chemistry Acridine derivatives Pharmaceutical Science Pharmacology (medical) Combinatorial chemistry
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :166-169
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2020.v13i6.35794
Popis:	Objective: The objective of the study was to synthesize and evaluate the anticancer activity of some novel acridine derivatives. Methods: The present works involve condensation of acridine and various 2, 4-Thiazolidine-2,4-dione derivatives (2a–2h) with chloroacetyl chloride to give a novel acridine derivatives (5a–5l), respectively. Results: All the newly synthesized molecules (5a–5l) were characterized by FTIR, H1-NMR, and mass spectral analysis along with physical data. The biological potentials of the new synthesized compounds are evaluated for their in vitro anticancer activity by MTT assay. Conclusion: The synthesized compounds 5a, 5f, and 5h exhibited good anticancer activity against MCF-7 and SKVO3 cancer cell lines at a concentration of 0.5 mg/mL-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7529574b7d66af21c06ca0c0d89569e9 https://doi.org/10.22159/ajpcr.2020.v13i6.35794 Zobrazit plný text záznamu