Can the genotype or phenotype of two polymorphic drug metabolising cytochrome P450-enzymes identify oral lichenoid drug eruptions?
| Autor: | Jesper Reibel, Siri Beier Jensen, L. A. Torpet, Birgitte Nauntofte, Camilla Kragelund, Claus Hansen, Kim Brøsen |
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| Rok vydání: | 2010 |
| Předmět: |
Drug
Cancer Research CYP2D6 biology media_common.quotation_subject Cytochrome P450 CYP2C19 Pharmacology medicine.disease Phenotype Pathology and Forensic Medicine stomatognathic diseases stomatognathic system Otorhinolaryngology Genotype Immunology medicine biology.protein Periodontics Oral lichen planus Oral Surgery Allele media_common |
| Zdroj: | Journal of Oral Pathology & Medicine. 39:497-505 |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/j.1600-0714.2010.00897.x |
| Popis: | J Oral Pathol Med (2010) 39: 497–505 Background: Lichenoid drug eruptions (LDE) in the oral cavity are adverse drug reactions (ADR) that are impossible to differentiate from oral lichen planus (OLP) as no phenotypic criteria exist. Impaired function of polymorphic cytochrome 450-enzymes (CYPs) may cause increased plasma concentration of some drugs resulting in ADR/LDE. In an earlier study we did not find more patients with OLP (OLPs) with impaired CYP-genotype. Objectives: To test if more OLPs have an impaired CYP-phenotype than to be expected from the CYP-genotype and to find clinical criteria characterising oral LDE. Methods: One hundred and twenty OLPs were genotyped for the most common polymorphisms of CYP2D6 and CYP2C19 that result in impaired function. One hundred and ten did a phenotype test of both enzymes. The exposure to drugs and polypharmacy and the CYP metabolism of the drugs were evaluated. The OLP manifestations were registered. Results: The only difference in OLP manifestations was that patients with a CYP2D6 genotype with less than two fully functional alleles presented more asymmetrical OLP distribution in particular in non-medicated patients (P |
| Databáze: | OpenAIRE |
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