Macrophage migration inhibitory factor − 794 CATT5−8 microsatellite polymorphism and susceptibility of tuberculosis

Autor: Gabriel Tassi Mousquer, Vitória Schmidt Caron, Graziele Lima Bello, Alana Ambos Freitas, Gisela Unis, Camila Anton, Felipe Dominguez Machado, Mirela Gehlen, Maria Lucia Rosa Rossetti, Rafaela Manzoni Bernardi, Denise Rossato Silva, Elis Regina Dalla Costa
Rok vydání: 2021
Předmět:
Zdroj: Infection. 49:457-461
ISSN: 1439-0973
0300-8126
DOI: 10.1007/s15010-020-01562-w
Popis: The establishment of candidate genetic determinants associated with tuberculosis (TB) is a challenge, considering the divergent frequencies among populations. The objective of this study was to evaluate the association between MIF − 794 CATT 5−8 polymorphism and susceptibility to TB. Case–control study. Patients > 18 years, with pulmonary TB were included. The control group consisted of blood donors and household contacts, not relatives, healthy and > 18 years. MIF − 794 CATT 5−8 were genotyped using sequencing of PCR and capillary electrophoresis. 126 patients and 119 controls were included. The genotype 5/5 was more frequent among cases (15.1%) than in controls (5.9%) (p = 0.019). Cases had more frequently the allele 5 (29.4%) as compared with controls (19.3%) (p = 0.010). Prevalence of 7/X + 8/X genotypes was not different between cases and controls (p = 0.821). There was no difference between patients with alleles 7 and 8 and those with alleles 5 and 6 (p = 0.608). The genotype 5/5 and the allele 5 of MIF − 794 CATT 5−8 were more frequent among TB patients than in controls.
Databáze: OpenAIRE
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