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Every year, large populations of primary malignant brain tumors are reported, of which approximately 70% are malignant gliomas. Over half of malignant glioma patients are of glioblastoma multiforme (GBM) linked with high mortality rates. The progression of GBM leads through several complicated pathways, which have also been expressed in the recurring segment. Previous researches have shown that various compounds found in edible plants, known colloquially as phytochemicals, can simultaneously influence multiple genetic pathways and can be used to treat GBM as a potential drug agent. Polysaccharides and flavonoids are among the phytochemicals extensively analyzed for their antioxidant, antineoplastic, and anti-inflammatory actions. Likewise, a broad detail of phytochemicals that have significant effects on GBM had been provided. Green nanoparticles have the ability to prevent or reverse carcinogenesis by halting or redirecting the start process or stopping the progression phase. Centered on a deep understanding of the intrinsic properties of GBM, such novel methods of drug delivery have demonstrated promise to overcome certain barriers. The BBB obstructs drug distribution to the brain and inhibits the efficacy of both old and new medications at the specified location. Because current GBM treatments are preventative instead of therapeutic, new delivery mechanisms are critical, and nanoparticles will be at the forefront of future initiatives. This chapter discusses the role of natural phytochemicals in enhancing glioblastoma patient expectancy and life expectancy by increasing treatment potential and reducing significant side effects. Furthermore, many novel GBM treatments will use better delivery systems and abandon the current approach of injecting medications and devices directly into the tumor. Nano-biotechnology, especially nanoparticles, contributes significantly to improving the delivery of drugs into carcinoma cells, and many of these technologies can be used in GBM. Finally, this chapter therefore emphasized the potential of natural products and novel drug delivery systems in GBM treatment by regulating multiple cancer pathways, such as toxicity reduction and side effects. |
