First stable α-diols and hemiketals from the α-halo pyruvamide series

Autor:	Alenka Majcen Le Marechal, Janja Pavc, Philippe Le Grel, Albert Robert
Rok vydání:	1997
Předmět:	chemistry.chemical_compound Series (mathematics) chemistry Precipitation (chemistry) Pyruvamide Organic Chemistry Drug Discovery Diastereomer Organic chemistry Alcohol Halo Biochemistry
Zdroj:	Tetrahedron. 53:13739-13748
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(97)00891-0
Popis:	The addition of water or alcohol to 3-halopyruvamides, having a special interest in enzymology, permitted us to isolate stable α-diols and hemiketals, until then detected only by spectroscopic means. The reaction is not diastereoselective, but selective precipitation of only one diastereoisomer shifts the equilibrium between the two isomers. Isolated compounds were fully characterised and results discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7521865f2414fa1194d244bb83758a04 https://doi.org/10.1016/s0040-4020(97)00891-0 Zobrazit plný text záznamu Full Text from ScienceDirect