Polymorphic haplotypes of the interleukin-10 5? flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis

Autor:	Pritash Patel, Esther Crawley, James E. Sillibourne, Ian V. Hutchinson, Patricia Woo, Richard A. Kay
Rok vydání:	1999
Předmět:	Genetics Oligoarthritis Immunology Haplotype 5' flanking region Arthritis Biology medicine.disease Phenotype Genetic determinism Rheumatology Genotype medicine Immunology and Allergy Pharmacology (medical) Juvenile rheumatoid arthritis
Zdroj:	Arthritis & Rheumatism. 42:1101-1108
ISSN:	1529-0131 0004-3591
DOI:	10.1002/1529-0131(199906)42:6<1101::aid-anr6>3.0.co;2-y
Popis:	Objective. To determine the distribution of the interleukin-10 (IL-10) 5' flanking region haplotypes in children with arthritis and in controls, and to investigate the functional significance of each haplotype. Methods. Sequence-specific oligonucleotide probing was used to determine haplotype frequency. Transient transfection studies were used to investigate the transcription of reporter genes driven by each haplotype. Whole blood cultures were performed to assess IL-10 production by each genotype. Results. Patients with arthritis involving >4 joints were more likely to have a genotype with an ATA haplotype than those whose arthritis remained restricted to
Databáze:	OpenAIRE
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