Biologically active quinazoline-based hydroxamic acids
| Autor: | Alexandr N. Balaev, D. S. Khachatryan, Vasily Nikolaevich Osipov |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
010405 organic chemistry media_common.quotation_subject Organic Chemistry Pharmacology toxicology Biological activity 01 natural sciences Combinatorial chemistry 0104 chemical sciences Molecular hybridization 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Quinazoline General Pharmacology Toxicology and Pharmaceutics Pharmacophore media_common |
| Zdroj: | Medicinal Chemistry Research. 29:831-845 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-020-02530-7 |
| Popis: | Molecular hybridization has become a new promising way to treat multifactorial diseases with a single compound that acts on multiple targets. The combination of several functional pharmacophore groups in one molecule can lead to a stronger therapeutic effect due to the ability to bind to several targets and possible synergistic interactions. The concept of multifunctional agents is being actively developed and has already produced some encouraging results. The quinazoline cycle and hydroxamic acids are unique pharmacophore groups that contribute to the structure of drug agents widely used in medical chemistry. The combination of these pharmacophores in one molecule leads to promising new compounds, which has been confirmed by many experimental studies in published literature across the world. Hybrid compounds of hydroxamic acids and the quinazoline cycle are a potential basis for the development of effective drugs used in the complex treatment of oncological, infectious and neurological diseases. This review provides information on the most significant developments in this area and discusses the bioactivity of important agents. Compounds with both linear hydroxamic acids and cyclic acids in which a hydroxamate group is integrated in the quinazoline ring are also covered in this review. |
| Databáze: | OpenAIRE |
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