Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry

Autor: Ningyi Li, Wenlin Xiao, Jian Pan, Zhuang Zhang, Longjiang Li, Zhuomin Wang
Rok vydání: 2010
Předmět:
Zdroj: Journal of Oral Pathology & Medicine. 40:127-134
ISSN: 0904-2512
DOI: 10.1111/j.1600-0714.2010.00953.x
Popis: J Oral Pathol Med (2011) 40: 127–134 Objectives: The aim of this study was to define the biomarkers of lymphatic spread which facilitate the appropriate therapy for oral tongue squamous cell carcinoma (OTSCC) patients at early stage. Here, we investigated the expression levels of seven biomarkers in oral squamous cell carcinoma (OSCC) tissues as well as their associations with the clinicopathologic features of OTSCC patients. Methods: The OTSCC samples were obtained from 138 patients undergoing tumor resection. Immunohistochemical staining was performed by using ColIA, ColIVA, Fn1, MMP-1, MMP-2, uPA, and D2-40 antibodies. Expression level of theses biomarkers in normal and tumor tissues were compared. Risk factors of lymphatic dissemination were evaluated by logistic regression equation. Results: LVD, MMP-1, MMP-2, and uPA in cancer tissues were significantly higher than those in normal tissue, and ColIA, ColIVA, and Fn1 in cancer tissue were significantly lower than those in normal tissue. Similar results were obtained from the comparison between metastatic tumor and non-metastatic tumor. All biomarker expressions were closely related with lymph node status and clinical stage. Additionally, the regression equation demonstrated that LVD is the risk factor of lymphatic metastasis in OTSCC patients (OR = 1.732; 95% CIs: 1.167–2.057; P
Databáze: OpenAIRE
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