Enzym-katalysierte Reaktionen, 8. Stereoselektive Darstellung von 2-Aminoalkoholen aus (R)- und (S)-Cyanhydrinen

Autor:	Franz Effenberger, Thomas Ziegler, Beate Gutterer
Rok vydání:	1991
Předmět:	Addition reaction chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Stereoselectivity Physical and Theoretical Chemistry Cyanohydrin Catalysis
Zdroj:	Liebigs Annalen der Chemie. 1991:269-273
ISSN:	1099-0690 0170-2041
DOI:	10.1002/jlac.199119910145
Popis:	Enzyme-Catalyzed Reactions, 8. – Stereoselective Synthesis of 2-Amino Alcohols from (R)- and (S)-Cyanohydrins erythro-2-Amino alcohols (1R,2S)- and (1S,2R)-4 may be synthesized stereoselectively by addition of Grignard compounds to cyanohydrins (R)-, (S)-1 and their O-trimethylsilyl derivatives 3, respectively, followed by hydrogenation. The threo-2-amino alcohols (1S,2S)- and (1R,2R)-4 are easily accessible by inversion at C-1 of the (1R,2S) and (1S,2R) compounds.
Databáze:	OpenAIRE
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