Evaluation of the retinal fiber layer thickness as a biomarker for sleep apnea syndrome
| Autor: | M Ara Gabarre, L. Gil-Arribas, A Ferreras Amez, P Calvo Perez, B Ferrandez Arenas, Maria Satue, M Bambo |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
genetic structures medicine.diagnostic_test business.industry Nerve fiber layer Sleep apnea Apnea Retinal General Medicine medicine.disease eye diseases Surgery Visual field Obstructive sleep apnea Ophthalmology chemistry.chemical_compound medicine.anatomical_structure chemistry Optical coherence tomography medicine sense organs medicine.symptom business Student's t-test |
| Zdroj: | Acta Ophthalmologica. 90 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.2012.4246.x |
| Popis: | Purpose To evaluate the peripapillary retinal nerve fiber layer (RNFL) thickness measured with spectral-domain optical coherence tomography (OCT) in obstructive sleep apnea syndrome (OSA) patients, as a biological marker of neuronal damage. Methods Sixty-four OSA patients and one hundred twenty-nine healthy controls were consecutive and prospectively selected. Only one eye per subject was randomly chosen. AOS patients were classified in three groups according to apnea/hipopnea index: mild, moderate and severe. All participants performed a comprehensive ophthalmologic examination and at least a reliable standard automated perimetry (SAP). Peripapillary RNFL thicknesses were measured with the Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). After checking for a normal distribution of variables, differences between both groups were tested by Student t test. Results Age was 50.6 ± 9.3 years in control eyes and 47.8 ± 11.5 years in AOS patients (p = 0.09). Mean deviation of SAP was -0.50 ± 1.0 dB and -1.4± 2.3 dB, in control and AOS patients, respectively (p |
| Databáze: | OpenAIRE |
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