Abstract P2-10-03: Metastasis-associated in colon cancer 1 predicts poor outcomes in patients with breast cancer

Autor:	Ji-Hee Lee, Mi-Young Park, Jeong-Young Cho, Ji-Hye Yoon
Rok vydání:	2013
Předmět:	Oncology MAPK/ERK pathway Cancer Research medicine.medical_specialty Tissue microarray business.industry Colorectal cancer Cancer medicine.disease Metastasis Breast cancer Internal medicine medicine Immunohistochemistry Hepatocyte growth factor business medicine.drug
Zdroj:	Cancer Research. 73:P2-10
ISSN:	1538-7445 0008-5472
DOI:	10.1158/0008-5472.sabcs13-p2-10-03
Popis:	Background: Metastasis-associated in colon cancer 1 (MACC1) plays a role in cancer invasion and metastasis through the upregulation of hepatocyte growth factor/mesenchymal epithelial transition-pathway, which is a known critical regulator of the mitogen-activated protein kinase (MAPK) cascades. However, the potential involvement of MACC1 in breast cancer has not been assessed. Materials and Methods: To investigate whether MACC1 expression is a prognostic marker in breast cancer, we performed immunohistochemical staining for MACC1 expression in tissue microarrays consisting of 198 invasive breast carcinomas. To demonstrate the potential correlation between MACC1 and MAPK cascades, phospho-p44/42 MAPK (ERK1/2) expression was also analyzed. Results: Expression of MACC1 was detected in 109 (55.1%) of 198 invasive breast carcinomas. MACC1 expression was significantly associated with several clinicopathologic parameters, including ER negativity (P < 0.01), PR negativity (p < 0.01), and HER-2 positivity (p < 0.01). The rate of metastatic relapse was significantly higher in the MACC1-positive group (87.8%, 36/41) than in the MACC1-negative group (46.5%, 73/157) (p < 0.001). MACC1 expression was significantly correlated with phospho-p44/42 MAPK expression (p < 0.05). On univariate survival analysis, a significant association was observed between MACC1 expression and decreased disease-free survival (p < 0.001) and overall survival (p = 0.001). On multivariate analysis, MACC1 expression was one of the statistically significant independent risk factors for disease-free survival (p = 0.001). Conclusion: Our results suggest that MACC1 may serve as a new parameter for the prognostic prediction in patients with invasive breast carcinoma. MACC1 is likely to be involved in the regulation of MAPK cascades in invasive breast carcinoma. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-10-03.
Databáze:	OpenAIRE
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