| Autor: |
Judith Blythe, Helmars Smits, Simonetta Masala, Thomas Pitterna, Edouard Godineau, Mohamed Abdelouahab Boussemghoune, Rupesh Patre, Patrik Hoegger, Juliane Vogt, Mukul Lal, Fabien Barreteau, Tomas Smejkal, C. S Prasanna, Jérôme Yves Cassayre, Peter Renold, Myriem El Qacemi, Guillaume Berthon, Torsten Luksch, Girish Rawal, Michael Flaeschel |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1016/b978-0-12-821035-2.00008-5 |
| Popis: |
Isocycloseram is a novel insecticide discovered at Syngenta Crop Protection. It is a new member of the isoxazoline class of insecticides, which acts as a noncompetitive antagonist of the invertebrate γ-aminobutyric acid (GABA) receptor at a site distinct to that of fiproles and cyclodienes and displays an excellent efficacy and selectivity against invertebrate pests. Innovative approaches for the delivery of modern agrochemicals such as multiparameter optimization and faster cycles of design-synthesis-test-analysis (DSTA) were applied to the discovery of isocycloseram. We will review in this chapter the synthesis, optimization, and biological efficacy aspects of this new chemical class. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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